What a fantastic book. I really picked it up on little more than the title, and the reputation of Mr. Lethem, although I have not read any of his other titles. A long flight from Philadelphia to San Jose, CA gave me a good chance to dive in and I was disappointed that I had to put it down to get off the plane!
The underlying plot is a rather typical hard-luck private eye story, but the environment is so unusual that the whole tale feels new and unique. The environment includes odd designer drugs like Forgettol, animals that have evolved to sentience, cryogenics, and the use of karma to determine when you no longer have any use to society.
I really liked the main character Conrad Metcalf and enjoyed watching him work on the edge of the law, trying to keep himself out of trouble, while identifying and battling the bad guys.
Great fun and highly recommended.